Article
Genotypic differences in the Chlamydia pneumoniae tyrP locus related to vascular tropism and pathogenicity.
The Journal of infectious diseases - 15 Oct 2003
Gieffers Jens, Durling Luke, Ouellette Scot P, Rupp Jan, Maass Matthias, Byrne Gerald I, Caldwell Harlan D, Belland Robert J
Abstract excerpt
Chlamydia pneumoniae is an obligate intracellular pathogen that causes respiratory infections and has been associated with cardiovascular disease. We compared respiratory and cardiovascular isolates to find genetic differences associated with pathogenicity. A polymorphic region encoding a tyrosine/tryptophan permease was found to differ between disease isolates. Respiratory strains contained multiple copies of...
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