Article
Type IIB von Willebrand's disease: gene mutations and clinical presentation in nine families from Denmark, Germany and Sweden.
British journal of haematology - 1 Sept 1992
Donnér M, Kristoffersson A C, Lenk H, Scheibel E, Dahlbäck B, Nilsson I M, Holmberg L
Abstract excerpt
Type IIB of von Willebrand's disease (vWD) is a variant in which the structurally abnormal von Willebrand factor (vWF) shows an increased affinity for the platelet vWF receptor, glycoprotein Ib (GPIb). This may sometimes give rise to platelet aggregation and thrombocytopenia in vivo. In 20 patien...
Topics
- Adult
- Aged
- Aged, 80 and over
- Family
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Pedigree
- Polymerase Chain Reaction
- Thrombocytopenia
- von Willebrand Diseases
- von Willebrand Factor