Clinical significance of gene-diagnosis for defects in coagulation factors and inhibitors.

Abstract excerpt

cDNA sequences of all known coagulation factors and inhibitors of coagulation have been described and an enormous number of disease generating mutations in these factors has been found by genetic analysis of affected families. The vast majority of these defects have severe clinical consequences such as spontaneous bleeding or predisposition to venous thrombosis and pulmonary embolism. While all the genetic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blood Coagulation Factors
• Share to Factor IX
• Share to Factor VIII