Article
[Progress in oncogene and antioncogene research].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Jun 1992
Toyoshima K, Akiyama T
Abstract excerpt
Recent progress in molecular biology of cancer revealed that mutations which potentiate the activities of proto-oncogenes create the oncogenes to force the growth of tumor cells. On the other hand, inactivation of antioncogenes results in the generations of tumor cells. The progression of many tumors to full malignancy requires both types of changes of the tumor cell genome.
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