Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virus.

doi:10.1099/0022-1317-73-11-2887

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Article

Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virus.

The Journal of general virology - 1 Nov 1992

Aguado B, Selmes I P, Smith G L

Abstract excerpt

A 21.8 kbp region of the genome of variola major virus (strain Harvey), a virus that caused haemorrhagic-type smallpox, has been sequenced and shown to possess 96% nucleotide identity to the corresponding region of vaccinia virus, the smallpox vaccine. Overall the gene arrangement in the two viruses is highly similar and individual open reading frames (ORFs) display a high degree of amino acid identity, for...

Topics

Amino Acid Sequence
Base Sequence
Conserved Sequence
DNA, Recombinant
Enzymes
Genes, Viral
Genetic Variation
Molecular Sequence Data
Open Reading Frames
Repetitive Sequences, Nucleic Acid
Restriction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Alignment

Sequence Homology, Nucleic Acid

Vaccinia virus

Variola virus

Viral Proteins

Viral Structural Proteins

Virulence

Source

Open in PubMed

Identifiers

PMID: 1331292
DOI: 10.1099/0022-1317-73-11-2887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1331292-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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