Article
Activation of a cryptic streptomycin-resistance gene in the Bacteroides erm transposon, Tn4551.
Molecular microbiology - 1 Aug 1992
Smith C J, Owen C, Kirby L
Abstract excerpt
Bacteroides compound transposons encoding erm resistance are highly homologous but previous studies have shown some divergence of Tn4551. Results presented here describe a novel Tn4551 streptomycin-resistance gene, aadS, that was phenotypically silent in wild-type Bacteroides. However, aadS expression could be activated by a trans-acting chromosomal mutation. The aadS-encoded peptide displayed significant...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Bacteroides
- Base Sequence
- DNA Transposable Elements
- DNA, Bacterial
- Drug Resistance, Microbial
- Gene Expression Regulation, Bacterial
- Molecular Sequence Data
- Mutation
- Nucleotidyltransferases