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Article

Latency and reactivation of a thymidine kinase-negative bovine herpesvirus 1 deletion mutant.

Archives of virology - 1 Jan 1992

Whetstone C A, Miller J M, Seal B S, Bello L J, Lawrence W C

Abstract excerpt

A bovine herpesvirus 1 (BHV 1) mutant variant with a deletion in the thymidine kinase (TK) gene was assessed for its ability to establish latency and be reactivated in cattle. After treatment with dexamethasone, reactivated TK- BHV 1 was isolated from one of four cattle that received virus by intravenous inoculation only, and from four of four cattle that received virus by intranasal, intravaginal, and...

Topics

Animals
Cattle
Cells, Cultured
Chromosome Deletion
Dexamethasone
Female
Herpesvirus 1, Bovine
Infectious Bovine Rhinotracheitis
Male
Mutation
Restriction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thymidine Kinase

Virus Activation

Source

Identifiers

PMID: 1309641
DOI: 10.1007/BF01321129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1309641-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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