Article
[The biological mechanisms of a congenital predisposition to alcoholism].
Fiziologicheskii zhurnal imeni I.M. Sechenova - 1 Dec 1992
Anokhina I P, Vekshina N L, Kuznetsova M N, Ovchinnikova L N, Stanishevskaia A V, Khristoliubova N A, Shamakina I Iu
Abstract excerpt
In descendants of white rats with chronic alcoholic intoxication, the contents of DA in the brain and blood plasma, characteristics of GABA and opiate brain receptors, the contents of cAMP and other substances were studied as well as the c-fos gene expression. The data obtained suggest a considerable role of the changes in the DA system functions in the genesis of pathology in these descendants.
Topics
- Alcoholism
- Animals
- Brain
- Brain Chemistry
- Disease Susceptibility
- Ethanol
- Female
- Gene Expression Regulation
- Genes, fos
- Genetic Predisposition to Disease
- Male