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Affinity Proteomics for Systematic Protein Profiling of Chromosome 21 Gene Products in Human Tissues

1 Jun 2003

Abstract excerpt

Here we show that an affinity proteomics strategy using affinity-purified antibodies raised against recombinant human protein fragments can be used for chromosome-wide protein profiling. The approach is based on affinity reagents raised toward bioinformatics-designed protein epitope signature tags corresponding to unique regions of individual gene loci. The genes of human chromosome 21 identified by the genome...

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PMID: 12796447
DOI: 10.1074/mcp.m300022-mcp200

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