Architectural abnormalities in muscle nuclei. Ultrastructural differences between X-linked and autosomal dominant forms of EDMD.

Abstract excerpt

OBJECTIVES: The aim of our study was to compare the ultrastructure of myonuclei in both forms of Emery-Dreifuss dystrophy (EDMD)-X-linked and dominantly autosomally transmitted. The muscle biopsies were taken from rectus femoris in four X-linked EDMD cases and three ADEDMD cases. METHODS: The biopsies were evaluated using immunocytochemical staining to establish emerin or A/C lamins deficiency. The muscle...

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