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Article

Role of beta-lactam carboxyl group on binding of penicillins and cephalosporins to class C beta-lactamases.

Proteins - 15 May 2003

Fenollar-Ferrer Cristina, Frau Juan, Donoso Josefa, Muñoz Francisco

Abstract excerpt

Molecular models for the Henry Michaelis complexes of Enterobacter cloacae, a class C beta-lactamase, with penicillin G and cephalotin have been constructed by using molecular mechanic calculations, based on the AMBER force field, to examine the molecular differentiation mechanisms between cephalosporins and penicillins in beta-lactamases. Ser318Ala and Thr316Ala mutations in both complexes and Asn346Ala and...

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PMID: 12696055
DOI: 10.1002/prot.10358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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