Article
Keratin 17 mutation in pachyonychia congenita type 2 with early onset sebaceous cysts.
The British journal of dermatology - 1 Mar 2003
Feng Y-G, Xiao S-X, Ren X-R, Wang W-Q, Liu A, Pan M
Abstract excerpt
BACKGROUND: Pachyonychia congenita (PC) is a group of autosomal dominant ectodermal dysplasias caused by mutations in four differentiation-specific keratin genes. Two major clinical subtypes of PC have been generally recognized. Symmetrically thickened fingernails and toenails are the defining characteristic of PC type 2 (PC-2) with onset at infancy. Pilosebaceous cysts are the best hallmark of PC-2, but they...
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