Article
Activation of the programmed cell death pathway by inhibition of proteasome function in plants.
The Journal of biological chemistry - 23 May 2003
Kim Moonil, Ahn Joon-Woo, Jin Un-Ho, Choi Doil, Paek Kyung-Hee, Pai Hyun-Sook
Abstract excerpt
Proteasomes constitute the major machinery to degrade or process proteins by ATP/ubiquitin-mediated proteolysis. Recent findings suggest a pivotal role of the ubiquitin/proteasome pathway in the regulation of apoptosis in animal cells. Here we show that virus-induced gene silencing of two different subunits of the 26 S proteasome, the alpha 6 subunit of the 20 S proteasome and RPN9 subunit of 19 S regulatory...
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