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Article

Molecular diagnosis of cystic fibrosis: comparison of four analytical procedures.

Clinical chemistry and laboratory medicine - 1 Jan 2003

Tomaiuolo Rossella, Spina Mariacristina, Castaldo Giuseppe

Abstract excerpt

We compared the analytical accuracy, times, costs and the detection rate of four procedures for the molecular analysis of cystic fibrosis (CF). DNA from 127 subjects bearing different genotypes was tested by denaturating gradient gel electrophoresis followed by sequencing (reference procedure) and, for comparison, by ASO dot-blot (in-house), reverse dot-blot (Innogenetics), ARMS (Zeneca Diagnostics) and OLA-PCR...

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Identifiers

PMID: 12636046
DOI: 10.1515/CCLM.2003.006

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