Article
Polymorphisms of sorbitol dehydrogenase (SDH) gene and susceptibility to diabetic retinopathy.
Medical hypotheses - 1 Apr 2003
Amano S, Yamagishi S, Koda Y, Tsuneoka M, Soejima M, Okamoto T, Inagaki Y, Yamada K, Kimura H
Abstract excerpt
The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. We along with others have recently found that SDH activity, the second step in the polyol pathway, might make a...
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