Article
Genomics of steroid hormones: in silico analysis of nucleotide sequence variants (polymorphisms) of the enzymes involved in the biosynthesis and metabolism of steroid hormones.
The Journal of steroid biochemistry and molecular biology - 1 Nov 2002
Igaz Peter, Pap Erna, Patócs Attila, Falus András, Tulassay Zsolt, Rácz Károly
Abstract excerpt
Alterations of steroid hormone biosynthesis and metabolism are suspected to be involved in the pathogenesis of several diseases. Several polymorphisms of the enzymes involved in these processes have already been described and some could be associated with certain diseases. We attempted to examine the sequence variants of these genes in order to find novel variants by an in silico analysis. We analyzed the known...
Topics
- Base Sequence
- Databases, Factual
- Genetic Variation
- Genomics
- Hormones
- Humans
- Open Reading Frames
- Polymorphism, Genetic
- Steroid Hydroxylases
- Steroids