Change in frequency of a rare mutant allele: a general formula and applications to partial inbreeding models.

Abstract excerpt

We deduce and prove a general formula to approximate the change in frequency of a mutant allele under weak selection, when this allele is introduced in small frequency into a population which was previously at a fixation state. We apply the formula to autosomal genes in partial selfing models and to autosomal as well as sex-linked genes in partial sib mating models. It is shown that the fate of a rare mutant...

Topics

• Alleles
• Gene Frequency
• Inbreeding
• Models, Genetic
• Mutation
• Selection, Genetic