Article
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.
The New England journal of medicine - 12 Dec 2002
Yamada Yoshiji, Izawa Hideo, Ichihara Sahoko, Takatsu Fumimaro, Ishihara Hitoshi, Hirayama Haruo, Sone Takahito, Tanaka Masashi, Yokota Mitsuhiro
Abstract excerpt
BACKGROUND: Although epidemiologic studies have suggested that several genetic variants increase the risk of myocardial infarction, large-scale association studies that examine many polymorphisms simultaneously are required to allow reliable prediction of the genetic risk of myocardial infarction. METHODS: We used a fluorescence- or colorimetry-based allele-specific DNA-primer-probe assay system to determine the...
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