Article
Peripheral neuropathy associated with mitochondrial disorders: 8 cases and review of the literature.
Journal of the peripheral nervous system : JPNS - 1 Dec 2002
Bouillot S, Martin-Négrier M L, Vital A, Ferrer X, Lagueny A, Vincent D, Coquet M, Orgogozo J M, Bloch B, Vita C
Abstract excerpt
Forty-three cases of peripheral neuropathy (PN) have been reported in the literature with a proven mitochondria (mt) DNA mutation, and 21 had a peripheral nerve biopsy (PNB). We studied 8 patients, 1 of whom had severe sensory PN, 3 mild PN, and 4 subclinical PN. Nerve biopsy was performed in every case; all patients showed axonal degeneration and 4 showed features of primary myelin damage. In addition, there...
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