Comparative Genomics Identifies the Genetic Islands That Distinguish Neisseria meningitidis , the Agent of Cerebrospinal Meningitis, from Other Neisseria Species

Abstract excerpt

Neisseria meningitidis colonizes the nasopharynx and, unlike commensal Neisseria species, is capable of entering the bloodstream, crossing the blood-brain barrier, and invading the meninges. The other pathogenic Neisseria species, Neisseria gonorrhoeae, generally causes an infection which is localized to the genitourinary tract. In order to investigate the genetic basis of this difference in disease profiles, we...

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