Article
Apolipoprotein E gene polymorphism alters lipids before pancreas transplantation.
Transplantation - 15 Oct 2002
Balakrishnan Sajeev, Colling Christopher, Burkman Tab, Erickson Judi, Lyden Elizabeth, Maheshwari Hiralal, Mack-Shipman Lynn, Lane James, Larsen Jennifer
Abstract excerpt
BACKGROUND: Pancreas transplantation (PTX) improves lipids in patients with type 1 diabetes mellitus. However, there are patients who have persistent abnormal lipids or develop new hyperlipidemia despite PTX. One factor that may influence the lipid profile is apolipoprotein E (Apo E) genotype. Apo E polymorphism, particularly E2 and E4 alleles, increases the risk of dyslipidemia. Apo E2 has also been found to...
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