Article
Interleukin-18 inhibits lodging and subsequent growth of human multiple myeloma cells in the bone marrow.
Oncology reports - 1 Jan 2000
Yamashita Kunihiro, Iwasaki Teruo, Tsujimura Tohru, Sugihara Ayako, Yamada Naoko, Ueda Haruyasu, Okamura Haruki, Futani Hiroyuki, Maruo Souji, Terada Nobuyuki
Abstract excerpt
An intravenous injection of ARH-77 cells (human multiple myeloma cell line) into mice with severe combined immunodeficiency disease (SCID mice) results in lodging of tumor cells in the bone marrow of thoracic and lumbar vertebrae, and in their subsequent growth, the cells destroying bone and invading the spinal cord and surrounding tissues, and the mice show hind leg paralysis. Using this model, we investigated...
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