Article
Cryptic t(12;15)(p13;q26) producing the ETV6-NTRK3 fusion gene and no loss of IGF2 imprinting in congenital mesoblastic nephroma with trisomy 11: fluorescence in situ hybridization and IGF2 allelic expression analysis.
Cancer genetics and cytogenetics - 1 Jul 2002
Watanabe Naoki, Kobayashi Hirofumi, Hirama Toshinori, Kikuta Atsushi, Koizumi Shoichi, Tsuru Tomomitsu, Kaneko Yasuhiko
Abstract excerpt
In the present fluorescence in situ hybridization (FISH) study of six congenital mesoblastic nephromas (CMNs) using ETV6 and NTRK3 probes as well as a chromosome 15 painting probe, we identified a cryptic reciprocal translocation, t(12;15)(p13;q26), in one tumor, and an insertion, ins(12;15)(p13;q22q26), in another that were not previously identified by cytogenetic analysis. An interphase FISH study with the same...
Topics
- Alleles
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 12
- Chromosomes, Human, Pair 15
- DNA-Binding Proteins
- Female
- Gene Expression
- Genomic Imprinting
- Histone-Lysine N-Methyltransferase