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Article

Late-onset hearing loss in a mouse model of DFN3 non-syndromic deafness: morphologic and immunohistochemical analyses.

Hearing research - 1 Apr 2002

Xia An-Ping, Kikuchi Toshihiko, Minowa Osamu, Katori Yukio, Oshima Takeshi, Noda Tetsuo, Ikeda Katsuhisa

Abstract excerpt

Recently, we reported that homozygous males and females of a mouse model of DFN3 non-syndromic deafness generated by the deletion of Brn-4 transcription factor showed profound deafness due to severe alterations in the cochlear spiral ligament fibrocytes from the age of 11 weeks, whereas no hearing loss was recognized in young female heterozygotes. It is known that a part of obligate female carriers of DFN3 showed...

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PMID: 12062767
DOI: 10.1016/s0378-5955(02)00309-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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