Article
Assessment of genomic instability in breast cancer and uveal melanoma by random amplified polymorphic DNA analysis.
International journal of cancer - 10 May 2002
Papadopoulos Sarantos, Benter Thomas, Anastassiou Gerasimos, Pape Michael, Gerhard Schaller, Bornfeld Norbert, Ludwig Wolf-Dieter, Dörken Bernd
Abstract excerpt
Some types of cancer have been associated with abnormal DNA fingerprinting. We used random amplified polymorphic DNA (RAPD) to generate fingerprints that detect genomic alterations in human breast cancer. Primers were designed by choosing sequences involved in the development of DNA mutations. Seventeen primers in 44 different combinations were used to screen a total of 6 breast cancer DNA/normal DNA pairs and 6...
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