Article
Generation of Campylobacter jejuni genetic diversity in vivo.
Molecular microbiology - 1 Apr 2002
de Boer Paulo, Wagenaar Jaap A, Achterberg René P, van Putten Jos P M, Schouls Leo M, Duim Birgitta
Abstract excerpt
Molecular epidemiology studies suggest that horizontal genetic exchange is a major cause of pathogen biodiversity. We tested this concept for the bacterial enteropathogen Campylobacter jejuni by seeking direct in vivo evidence for the exchange of genetic material among Campylobacter strains. For this purpose, two antibiotic resistance markers were inserted into the hipO or htrA gene of genetically distinct and...
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