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Article

Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

Brooks Andrew I, Stein Colleen S, Hughes Stephanie M, Heth Jason, McCray Paul M, Sauter Sybille L, Johnston Julie C, Cory-Slechta Deborah A, Federoff Howard J, Davidson Beverly L

Abstract excerpt

Gene transfer vectors based on lentiviruses can transduce terminally differentiated cells in the brain; however, their ability to reverse established behavioral deficits in animal models of neurodegeneration has not previously been tested. When recombinant feline immunodeficiency virus (FIV)-based vectors expressing beta-glucuronidase were unilaterally injected into the striatum of adult beta-glucuronidase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11959904
DOI: 10.1073/pnas.082011999
PMCID: PMC122929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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