Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequencies.

doi:10.1007/s00439-001-0668-0

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Article

Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequencies.

Human genetics - 1 Mar 2002

Uinuk-Ool Tatiana S, Takezaki Naoko, Sukernik Rem I, Nagl Sandra, Klein Jan

Abstract excerpt

Gene frequencies of eight Siberian populations (Mansi, Tuva, Todja, Tofalar, Buryat, Okhotsk Evenki, Ulchi, and Negidal) were determined for the three most polymorphic HLA class II loci ( DRB1, DQA1, and DQB1) by a combination of single-stranded conformational polymorphism typing and DNA sequencing. The number of alleles per population ranged from 16 to 25, from seven to eight, and from nine to 14 for the DRB1,...

Topics

Alleles
Americas
Asia
DNA
Ethnicity
Gene Frequency
Genes, MHC Class II
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DR Antigens
HLA-DRB1 Chains
Haplotypes
Humans
Models, Genetic
Phylogeny
Polymorphism, Single-Stranded Conformational
Siberia

Source

Open in PubMed

Identifiers

PMID: 11935333
DOI: 10.1007/s00439-001-0668-0

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