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Article

Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene.

American journal of human genetics - 1 Feb 2002

Vincent Andrea L, Billingsley Gail, Buys Yvonne, Levin Alex V, Priston Megan, Trope Graham, Williams-Lyn Donna, Héon Elise

Abstract excerpt

"Early-onset glaucoma" refers to genetically heterogeneous conditions for which glaucoma manifests at age 5-40 years and for which only a small subset is molecularly characterized. We studied the role of MYOC, CYP1B1, and PITX2 in a population (n=60) affected with juvenile or early-onset glaucoma from the greater Toronto area. By a combination of single-strand conformation polymorphism and direct cycle...

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Source

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Identifiers

PMID: 11774072
DOI: 10.1086/338709
PMCID: PMC384919

Genes

MYOC
PITX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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