Article
[The prevalence of beta-thalassemia heterozygotes compound alpha-thalassemia in Guangdong district].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Oct 2001
Han J, Zeng R, Hu B
Abstract excerpt
OBJECTIVE: To investigate the prevalence of beta-thalassemia (beta-thal) heterozygotes compound alpha-thal in Guangdong area. METHODS: alpha-thal 1 genes were amplified in 500 beta-thal carriers diagnosed by reverse dot blotting (RDB) using gap-PCR method, alpha-thal 2 genes were detected in 400 of the 500 beta-thal carriers using Southern blotting with alpha-globin DNA probe and restrict endonuclease zymogram...
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