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Article

High risk for unbalanced segregation of some reciprocal translocations: a large pedigree containing distal 4q trisomy from t(4;7)(q28;p22).

American journal of medical genetics - 1 Nov 2001

Francisco-Bagnariolli A M, Payão S L, Kawasaki-Oyama R S, Sabbag Filho D, Segato R, de Labio R W, Chauffaille M L, Priest J H

Abstract excerpt

We report on a familial t(4;7)(q28;p22) with 2:2 adjacent-1 unbalanced segregation producing duplication of 4q28-->qter in multiple offspring. Within the large four-generation pedigree, a carrier had a reproductive outcome that was approximately equal for 1) the balanced translocation, 2) normal chromosomes, and 3) viable 4q trisomy or pregnancy loss. The three individuals with chromosomal confirmation of trisomy...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 11746010

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Source receipt: pubmed, retrieved 7 Sept 2026.

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