Article
Detection of submicroscopic aberrations in patients with unexplained mental retardation by fluorescence in situ hybridization using multiple subtelomeric probes.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2000
Fan Y S, Zhang Y, Speevak M, Farrell S, Jung J H, Siu V M
Abstract excerpt
PURPOSE: To further assess the frequency of subtelomeric aberrations in a selected population and to examine the feasibility of a clinical testing. METHODS: Patients were selected based on the following criteria: (1) mental retardation (IQ < 70) or developmental delay with dysmorphic features; (2) a normal karyotype at the level of resolution of 450 to 500 bands; and (3) exclusion of other possible etiologies by...
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