Expression of AP‐2 transcription factor and of its downstream target genes c‐kit, E‐cadherin and p21 in human cutaneous melanoma

Abstract excerpt

The AP-2 transcription factor plays a pivotal role in regulating the expression of several genes involved in tumor growth and progression of melanoma. We determined, by Western blot, variation in the level of expression of AP-2 and three of its downstream targets, c-kit, E-cadherin, and p21 in several human melanoma cell lines and, by immunohistochemistry, in a group of 99 histological samples including benign...

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