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Article

Loss of heterozygocity at the thyroid peroxidase gene locus in solitary cold thyroid nodules.

Thyroid : official journal of the American Thyroid Association - 1 Aug 2001

Krohn K, Paschke R

Abstract excerpt

Germline mutations in both alleles of the thyroid peroxidase (TPO) gene have been reported as a frequent cause of congenital hypothyroidism resulting from a total iodide organification defect (TIOD). Because TPO mutations have a prevalence of 1 in 66,000 newborns and is inherited in an autosomal recessive mode the frequency of a heterozygous germline mutation in the TPO gene should reach about 1 in 260 in the...

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Source

Identifiers

PMID: 11525266
DOI: 10.1089/10507250152484574

Genes

TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of heterozygocity at the thyroid peroxidase gene locus in solitary cold thyroid nodules.PMID 11525266Read ↗

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