Article
Congenital insensitivity to pain with anhidrosis.
Pediatric neurology - 1 Jul 2001
Sztriha L, Lestringant G G, Hertecant J, Frossard P M, Masouyé I
Abstract excerpt
Congenital insensitivity to pain with anhidrosis is an autosomal-recessive disorder resulting from defective neural crest differentiation with loss of the first-order afferent system, which is responsible for pain and temperature sensation. There is also a neuronal loss in the sympathetic ganglia. Lack of sweating, hyperthermia, and infections of bones are main features of the disorder; however, contradictory...
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