Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular and genealogical evidence for a founder effect in Fanconi anemia families of the Afrikaner population of South Africa.

Proceedings of the National Academy of Sciences of the United States of America - 8 May 2001

Tipping A J, Pearson T, Morgan N V, Gibson R A, Kuyt L P, Havenga C, Gluckman E, Joenje H, de Ravel T, Jansen S, Mathew C G

Abstract excerpt

Fanconi anemia (FA) is a rare, genetically heterogeneous autosomal recessive disorder associated with progressive aplastic anemia, congenital abnormalities, and cancer. FA has a very high incidence in the Afrikaner population of South Africa, possibly due to a founder effect. Previously we observed allelic association between polymorphic markers flanking the FA group A gene (FANCA) and disease chromosomes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia

Share to Founder Effect

Share to Genealogy and Heraldry

Share to Haplotypes

Share to Pedigree

Share to South Africa

Source

Open in PubMed Open full text

Identifiers

PMID: 11344308
DOI: 10.1073/pnas.091402398
PMCID: PMC33282

Genes

FANCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular and genealogical evidence for a founder effect in Fanconi anemia families of the Afrikaner population of South Africa.PMID 11344308Read ↗

Spectrum of sequence variations in the FANCA gene: an International Fanconi Anemia Registry (IFAR) study.Semantic proximity Read ↗

Common and Founder Mutations for Monogenic Traits in Sub-Saharan African Populations.Semantic proximity Read ↗

The causes of Fanconi anemia in South Asia and the Middle East: A case series and review of the literature.Semantic proximity Read ↗

Fanconi anemia founder mutation in Macedonian patients.Semantic proximity Read ↗

Fanconi anemia in Tunisia: high prevalence of group A and identification of new FANCA mutations.Semantic proximity Read ↗

Fanconi Anemia Patients from an Indigenous Community in Mexico Carry a New Founder Pathogenic Variant in FANCGSemantic proximity Read ↗

Clinical, cytogenetic and molecular findings in nine Moroccan patients with Fanconi anemia.Semantic proximity Read ↗

Novel Founder Mutation in FANCA Gene (c.3446_3449dupCCCT) Among Romani Patients from the Balkan Region.Semantic proximity Read ↗

Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations.Semantic proximity Read ↗

Five Novel Deleterious Variants in FANCA, FANCF and FANCG Identified in Pakistani Fanconi Anemia Families Using Exome SequencingSemantic proximity Read ↗

Alu-Mediated Deletion of FANCA in Turkish Families With Fanconi Anemia: Evidence of a Founder Effect.Semantic proximity Read ↗

Clinical and genetic features of Fanconi anemia associated with a variant of FANCA gene: Case report and literature review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.