Article
Monitoring of minimal residual disease in children with acute promyelocytic leukemia by RT-PCR detecting PML/RARalpha chimeric gene: a retrospective study of clinical feasibility.
The Tohoku journal of experimental medicine - 1 Feb 2001
Suzuki H, Imaizumi M, Sato A, Yoshinari M, Rikiishi T, Endo M, Takano T, Shimizu T, Hatae Y, Fujimoto T, Hayashi Y, Iinuma K
Abstract excerpt
We studied retrospectively the clinical feasibility of minimal residual disease (MRD) monitoring by reverse transcription-polymerase chain reaction (RT-PCR) detecting the PML/retinoic acid receptor alpha (RARalpha) chimeric gene in children with acute promyelocytic leukemia (APL). MRD monitoring of APL was performed with standard and nested RT-PCR for PML/RARalpha gene, the sensitivity of which was 1 leukemic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.