Canine Model and Genomic Structural Organization of Glycogen Storage Disease Type Ia (GSD Ia)

doi:10.1354/vp.38-1-83

Article

Canine Model and Genomic Structural Organization of Glycogen Storage Disease Type Ia (GSD Ia)

1 Jan 2001

Abstract excerpt

A canine model of glycogen storage disease Ia (GSD Ia), similar clinically, biochemically, and pathologically to the human disease, was established by crossbreeding Maltese and Beagle dogs carrying a mutated, defective glucose-6-phosphatase (G-6-Pase) gene. Ten puppies were born in three litters from these crossbreedings. Six were homozygous for the previously described M121I GSD Ia mutation. Of these six...

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