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Article

A Plasticity‐Based Theory of the Pathogenesis of Alzheimer's Disease

1 Dec 2000

Abstract excerpt

Amyloid plaques (APs) and neurofibrillary tangles (NFTs) are the two diagnostic markers of Alzheimer's disease (AD). The neuropsychological features of AD are closely correlated with the distribution of the NFTs and therefore favor a disease process revolving around neurofibrillary degeneration. The genetics, however, favor a disease process revolving around the APs, principally because mutations in the amyloid...

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PMID: 11193801
DOI: 10.1111/j.1749-6632.2000.tb05559.x

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