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Article

High risk of infertility and long term gonadal damage in males treated with high dose cyclophosphamide for sarcoma during childhood

1 Jan 2001

Abstract excerpt

BACKGROUND: Therapy with alkylating agents, such as cyclophosphamide, can be associated with irreversible gonadal toxicity in male survivors of adult cancer. To the authors's knowledge the effect of high dose therapy with cyclophosphamide during childhood on adult testicular reproductive and endocrine function has not been established. METHODS: Gonadal function was studied in 17 adult male survivors of childhood...

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PMID: 11169946
DOI: 10.1002/1097-0142(20010201)91:3<613::aid-cncr1042>3.0.co;2-r

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