Article
The molecular basis and clinical management of ataxia telangiectasia.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 1 Aug 2000
Spacey S D, Gatti R A, Bebb G
Abstract excerpt
The unique combination of phenotypic manifestations seen in ataxia telangiectasia (AT) has intrigued neurologists, oncologists, radiation biologists and immunologists for several decades. Initially, the primary care givers of AT patients are often pediatricians but neurologists will inevitably become involved in their care. Over the last few years great strides have been made in understanding the genetic basis of...
Topics
- Animals
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- DNA-Binding Proteins
- Genetic Counseling
- Genetic Variation
- Heterozygote
- Humans
- Mice
- Mice, Knockout
- Prenatal Diagnosis
- Protein Serine-Threonine Kinases
- Tumor Suppressor Proteins