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Article

Cellular and viral splicing factors can modify the splicing pattern of CFTR transcripts carrying splicing mutations.

Human molecular genetics - 22 Jul 2000

Nissim-Rafinia M, Chiba-Falek O, Sharon G, Boss A, Kerem B

Abstract excerpt

Variable levels of aberrantly spliced cystic fibrosis transmembrane conductance regulator (CFTR ) transcripts were suggested to correlate with variable cystic fibrosis (CF) severity. We studied the effect of the cellular splicing factors, hnRNP A1 and ASF/SF2, and their adenoviral analogues, E4-ORF6 and E4-ORF3, that promote exon skipping and/or exon inclusion, on the splicing pattern of the CFTR mutation...

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Identifiers

PMID: 10915765
DOI: 10.1093/hmg/9.12.1771

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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