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Article

[In vitro contracture test and gene typing in diagnosing malignant hyperthermia. Each as an appropriate complement to the other method].

Der Anaesthesist - 1 Feb 2000

Rüffert H, Olthoff D, Deutrich C, Thamm B, Froster U

Abstract excerpt

BACKGROUND: Malignant hyperthermia (MH) is an autosomal dominantly inherited disorder, triggered in susceptible individuals by inhalation anesthetics and depolarizing muscle relaxants such as succinylcholine. Because of its high sensitivity (97-99%) and specificity (93.6%) as well as the genetic heterogeneity of MH disorder, the in vitro contracture test (IVCT) following the European-MH-Group is considered to be...

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Source

Identifiers

PMID: 10756965
DOI: 10.1007/s001010050017

Genes

RYR1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia.Semantic proximity Read ↗

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Homozygous and heterozygous Arg614Cys mutations (1840C-->T) in the ryanodine receptor gene co-segregate with malignant hyperthermia susceptibility in a German family.Semantic proximity Read ↗

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