Evolution of the apolipoprotein B gene and coronary artery disease: a study in low and high risk Asians.

doi:10.1046/j.1469-1809.1999.6310045.x

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Article

Evolution of the apolipoprotein B gene and coronary artery disease: a study in low and high risk Asians.

Annals of human genetics - 1 Jan 1999

Heng C K, Saha N, Low P S

Abstract excerpt

This study traces the evolutionary pathways of the apolipoprotein B gene in the low risk Chinese and high risk Asian Indians in relation to coronary artery disease (CAD). Haplotypes were constructed from six apoB polymorphisms sp24/27, Ag(c/g), Ag(a1/d), XbaI, Ag(h/i) and, Ag(t/z). These were genotyped from 474 Chinese (253 healthy, 221 CAD patients) and 248 Asian Indians (164 healthy, 84 CAD patients). The...

Topics

Apolipoproteins B
Base Sequence
Biological Evolution
Case-Control Studies
China
Coronary Disease
DNA Primers
Female
Gene Frequency
Genotype
Haplotypes
Humans
India
Linkage Disequilibrium
Male
Polymorphism, Genetic
Risk Factors
Singapore

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PMID: 10738520
DOI: 10.1046/j.1469-1809.1999.6310045.x

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