Article
Common trisomy mosaicism diagnosed in amniocytes involving chromosomes 13, 18, 20 and 21: karyotype-phenotype correlations.
Prenatal diagnosis - 1 Feb 2000
Wallerstein R, Yu M T, Neu R L, Benn P, Lee Bowen C, Crandall B, Disteche C, Donahue R, Harrison B, Hershey D, Higgins R R, Jenkins L S, Jackson-Cook C, Keitges E, Khodr G, Lin C C, Luthardt F W, Meisner L, Mengden G, Patil S R, Rodriguez M, Sciorra L J, Shaffer L G, Stetten G, Van Dyke D L, Wang H
Abstract excerpt
Karyotype-phenotype correlations of common trisomy mosaicism prenatally diagnosed via amniocentesis was reviewed in 305 new cases from a collaboration of North American cytogenetic laboratories. Abnormal outcome was noted in 10/25 (40%) cases of 47,+13/46, 17/31 (54%) cases of 47,+18/46, 10/152 (6.5%) cases of 47,+20/46, and in 49/97 (50%) cases of 47,+21/46 mosaicism. Risk of abnormal outcome in pregnancies with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.