Article
Imprinting effect in premature ovarian failure confined to paternally inherited fragile X premutations.
American journal of human genetics - 1 Feb 2000
Hundscheid R D, Sistermans E A, Thomas C M, Braat D D, Straatman H, Kiemeney L A, Oostra B A, Smits A P
Abstract excerpt
Fragile X premutations are considered to be a risk factor for premature ovarian failure (POF), which is usually defined as menopause at age <40 years. Since premutations may be inherited from either the mother or the father, we evaluated the influence of the inheritance pattern on the duration of reproductive life in female carriers. The occurrence of POF and age at menopause in women with a paternally inherited...
Topics
- Adult
- Age of Onset
- Fathers
- Female
- Fragile X Mental Retardation Protein
- Fragile X Syndrome
- Genetic Predisposition to Disease
- Genomic Imprinting
- Heterozygote
- Humans
- Male
- Menopause
- Menstrual Cycle
- Middle Aged