Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recent advances in Canavan disease.

Advances in pediatrics - 1 Jan 1999

Matalon R, Michals-Matalon K

Abstract excerpt

More studies are needed to elucidate the pathophysiology of Canavan disease and how the inability to hydrolyze NAA leads to spongy degeneration. The creation of an animal model would be helpful in the understanding of the disease and the formulation of gene therapy.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Testing
Share to Jews
Share to Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amidohydrolases

Share to Aspartic Acid

Share to Diagnosis, Differential

Share to Disease Models, Animal

Share to Genetic Counseling

Source

Identifiers

PMID: 10645473

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recent advances in Canavan disease.PMID 10645473Read ↗

The pathogenesis of, and pharmacological treatment for, Canavan diseaseSemantic proximity Read ↗

Molecular basis of Canavan disease.Semantic proximity Read ↗

Biochemistry and molecular biology of Canavan disease.Semantic proximity Read ↗

Molecular basis of Canavan's disease: from human to mouse.Semantic proximity Read ↗

Therapeutic Options in Prevention and Treatment of Aspartoacylase Gene Mutation Resulting Abnormalities in Canavan Disease.Semantic proximity Read ↗

Spongy degeneration of the brain, canavan disease: biochemical and molecular findingsSemantic proximity Read ↗

Canavan disease: studies on the knockout mouse.Semantic proximity Read ↗

Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy.Semantic proximity Read ↗

Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system.Semantic proximity Read ↗

Novel mutation in an Egyptian patient with infantile Canavan disease.Semantic proximity Read ↗

Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for canavan disease.Semantic proximity Read ↗

Two patients with Canavan disease and structural modeling of a novel mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.