Article
Increased cerebrospinal fluid glycine: a biochemical marker for a leukoencephalopathy with vanishing white matter.
Journal of child neurology - 1 Nov 1999
van der Knaap M S, Wevers R A, Kure S, Gabreëls F J, Verhoeven N M, van Raaij-Selten B, Jaeken J
Abstract excerpt
Recently, a new disease entity has been defined: the disease of vanishing white matter. This leukoencephalopathy has an autosomal-recessive mode of inheritance. No cause or biochemical marker is known. We studied cerebrospinal fluid amino acids in five patients with the disease and found a consistent, moderate elevation of cerebrospinal fluid glycine in all. The ratio of cerebrospinal fluid to plasma glycine was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.