Article
Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyperinsulinemia and an SstI polymorphism.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1999
Sijbrands E J, Hoffer M J, Meinders A E, Havekes L M, Frants R R, Smelt A H, De Knijff P
Abstract excerpt
More than 90% of patients with type III hyperlipoproteinemia are homozygous carriers of the apolipoprotein (apo) E*2 allele. The great majority of these apoE2(Arg158-->Cys) homozygotes in the general population, however, are normolipidemic. Apparently, expression of the hyperlipidemic state requires additional genetic and/or environmental factors, suggesting a multifactorial etiology. To elucidate these...
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