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Adeno-Associated Virus Vectors and Hematology

1 Aug 1999

Abstract excerpt

Gene therapists have a special fondness for hematology. Initially, this was due to the many inherited diseases that could potentially be cured by ex vivo genetic modification of hematopoietic stem cells. Once the early murine leukemia virus (MLV) vectors were found to transduce only a small percentage of primate stem cells, the search began for other types of vectors that might work more efficiently, and...

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PMID: 10419876
DOI: 10.1182/blood.v94.3.864.415k34_864_874

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